19. The hypoglycemic effect of gynostemma compressum x.X. Chen & d.R. Liang in type 2 diabetic mice
Main Article Content
Abstract
Gynostemma, a precious medicinal plant with many pharmacological effects reported worldwide, has a blood glucose lowering effect. There are many different species of Gynostemma. In Vietnam, 6 species have been discovered, of which Gynostemma compressum X.X. Chen & D.R. Liang has not been studied yet. The purpose of this research is to investigate the hypoglycemic action of Gynostemma compressum X.X. Chen & D.R. Liang in type 2 diabetic mice. The research was conducted by combining a high fat diet for 8 weeks and STZ induced type 2 diabetes in mice. The chemicals were used are STZ 100mg/kg bw i.p route, gliclazid 80mg/kg bw oral route, the ethanol extract of Gynostemma compressum X.X. Chen & D.R. Liang at 0,96g/kg and 2,88g/kg bw, oral route, during 2 weeks. Gynostemma compressum X.X. Chen & D.R. Liang at two doses had glucose – lowering effect and liver protection, pancreas structure improvement in type 2 diabetic mice for 2 weeks treatment.
Article Details
Keywords
Type 2 diabetic mice, high fat diet, STZ, Gynostemma compressum X.X. Chen & D.R. Liang, Gynostemma
References
2. Norberg A, Nguyen Khanh Hoa, Dao Van Phan, et al. A Novel Insulin-releasing Substance, Phanoside, from the plant Gynostemma pentaphyllum. Journal of Biologycal Chemistry. 2004; 279: 41361 - 41367.
3. Samer Megalli, Neal M. Davies, Basil D Roufogalis. Ant i- Hyperlipidemic and Hypoglycemic Effect of Gynostemme pentaphyllum in the Zucker fatty Rat. J Pharm Pharmaceut Sci. 2006; 9(3): 281 - 291.
4. Zhang, Yumeng & Shi, Guohui & Luo, et al. Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets. Network Pharmacology Approach. Molecules. 2021; 26: 3006. 10.3390/molecules26103006.
5. Kim, Yoon & Kim, So & Lee, Jae & Jo, et al (2019). The Efficacy of Gynostemma pentaphyllum Extract in Anti-obesity Therapy. Records of Natural Products. 2019; 14: 116-128. 10.25135/rnp.146.19.05.1270.
6. Rivera R.F., Escalona C.N., Garduno S.L. et al. Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice fed a high fat diet with fructose. Journal of Biomedicine and Biotechnology, Epub 2011 Nov 17, doi: 10.1155/2011/968984.
7. Srinivasan K., Ramarao P. Animal models in type 2 diabetes research: An over view. Indian Journal of Medicine Research 2007; 125: 451 - 472.
8. Ullah Asmat, Khan Abad, Khan Ismail. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharmaceutical Journal. 2016; 24 (5): 547-553.
9. Ji Hong Lian, Youqing X., Lei G. et al. The use of High Fat/Carbohydrate Diet-Fed and Streptozotocin-Treated Mice as a Suitable Animal Model of Type 2 Diabetes Mellitus. Scand. J. Lab. Anim. Sci. 2007; 34(1): 21-29.
10. Gao D, Zhao M, Qi X, et al. Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats. Arch Pharm Res. 2016; 39(2): 221 - 230. doi:10.1007/s12272-014-0441-2.
11. Dinh TTT, Nguyen TT, Ngo HT, et al. Dammarane-type triterpenoids from Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) and their AMPK activation effect in 3T3-L1 cells [published online ahead of print, 2022 Apr 28]. Phytochemistry. 2022; 200: 113218. doi:10.1016/j.phytochem.2022.113218.
12. Tống Tiểu Hoa, Vũ Thị Bạch Phượng, Dương Công Kiên và CS. Khảo sát hoạt tính sinh học cây Giảo cổ lam (Gynostemma pentaphyllum Thunb. Makino). Tạp chí Phát triển Khoa học và Công nghệ: Chuyên san Khoa học Tự nhiên. 2017; 1(6): 49-56.
13. Bae U. J. et al. Gypenoside UL4-Rich Gynostemma pentaphyllum extract exerts a hepatoprotective effect on diet-induced nonalcoholic fatty liver disease. The American journal of Chinese medicine, 2018; 46(6): 1315-1332. doi: 10.1142/s0192415x18500696.