34. Nghiên cứu tác dụng điều trị viêm loét dạ dày của cao chiết lá Sanchezia nobilis Hook.F trên thực nghiệm

Abstract

Sanchezia nobilis Hook.F has been used as a traditional precious medicine to cure gastritis. The ethanol extract (total extract) of the Sanchezia nobilis Hook.F leaves was evaluated for its effects on peptic ulcers. Pyloric ligation model was conducted by Shay method on Wistar rats at 3 doses of 450 mg/kg, 150 mg/kg and 50 mg/kg. Study on analgesic effect on hot plate and pain threshold meter at 2 doses of 300 mg/kg and 900 mg/kg was conducted in Swiss mice. The results showed that both dose of 450 mg/kg and 150 mg/kg of the whole leaf extract decreased the mean ulcer score, ulcer index, free acidity, total acidity, the gastric volume; increased the pH and improved in macroscopic and microscopic images were also observed; however, there was no change in these parameters with the 50 mg/kg dose when compared with the model group. With both doses of 300 mg/kg/day and 900 mg/kg/day, no analgesic effect was observed on the hot plate model and the pain threshold meter. In conclusion, Sanchezia nobilis Hook.F had potential effect against gastric ulcers in experimental rats, however at both doses of 300 mg/kg/day and 900 mg/kg/day, there was no analgesic effects in the mouse hot-plate and pain threshold test.